The doses of ketamine used for depression and anxiety at OnlyMed can vary depending on several factors, including the patient's weight, medical history, and the specific treatment protocol being used. Additionally, the route of administration can also impact the dosing.
For intravenous (IV) and (IM) ketamine, which is the most common route used in clinics, the initial dose can range from 0.5 to 1 mg/kg. This may be followed by additional doses, depending on the treatment protocol being used. Some clinics may use a fixed dose of ketamine, such as 0.5 mg/kg, while others may use a weight-based dosing strategy.
For intranasal (IN) ketamine, which is a newer route of administration that is gaining popularity, the dosing can vary depending on the concentration of the ketamine solution and the volume of the nasal spray. In general, the dosing for IN ketamine is lower than IV ketamine, with initial doses ranging from 28 to 84 mg.
It's important to note that the dosing of ketamine for depression and anxiety is still an area of active research and may vary among clinics and providers. Additionally, the dosing may be adjusted based on the patient's response and any side effects that may occur. The importance of doing this novel therapy in the presence of a Board Certified Physician is of utmost importance.
Ketamine use can cause several side effects, which may vary depending on the dose, route of administration, and individual factors such as age and medical history. Here are some common side effects of ketamine use:
Psychological side effects: Ketamine is known to cause dissociative and hallucinogenic effects, which may include feelings of detachment from oneself or one's surroundings, altered perception of time, visual and auditory hallucinations, and changes in thought patterns. These effects can be unsettling for some people and may increase the risk of accidents or injuries.
Cardiovascular side effects: Ketamine can cause changes in heart rate and blood pressure, which may be more pronounced at higher doses. This can lead to complications such as heart palpitations, arrhythmias, or even cardiac arrest.
Respiratory side effects: Ketamine can also cause respiratory depression, which may be more likely to occur in patients with preexisting respiratory conditions or when ketamine is used in combination with other sedatives or opioids.
Gastrointestinal side effects: Ketamine can cause nausea, vomiting, and loss of appetite, which may be more likely to occur at higher doses.
Cognitive side effects: Some people may experience cognitive impairments such as confusion, memory loss, or difficulty with concentration or decision-making.
Addiction and abuse: Ketamine has the potential for abuse and addiction, particularly in individuals with a history of substance use disorders.
It's important to note that the risk of side effects may be reduced by using appropriate doses, monitoring vital signs, and providing a safe and supportive environment during ketamine treatment. Additionally, patients should be informed of the potential risks and benefits of ketamine use before undergoing treatment.
B.R. Khoury, DO
Chief Medical Officer Board Certified Physician
Professor of Medicine, Valparaiso University